Empirical fitness landscapes and the predictability of evolution
JAGM De Visser, J Krug - Nature Reviews Genetics, 2014 - nature.com
The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …
yet it has mostly been used as a superficial metaphor because we know little about its …
Perspective: evolution and detection of genetic robustness
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of
phenotypes appears at various levels of biological organization, including gene expression …
phenotypes appears at various levels of biological organization, including gene expression …
The evolution of genetic architecture
TF Hansen - Annu. Rev. Ecol. Evol. Syst., 2006 - annualreviews.org
Genetic architecture, the structure of the mapping from genotype to phenotype, determines
the variational properties of the phenotype and is instrumental in understanding its …
the variational properties of the phenotype and is instrumental in understanding its …
Quantitative analyses of empirical fitness landscapes
IG Szendro, MF Schenk, J Franke, J Krug… - Journal of Statistical …, 2013 - iopscience.iop.org
The concept of a fitness landscape is a powerful metaphor that offers insight into various
aspects of evolutionary processes and guidance for the study of evolution. Until recently …
aspects of evolutionary processes and guidance for the study of evolution. Until recently …
Perspective: spontaneous deleterious mutation
Mildly deleterious mutation has been invoked as a leading explanation for a diverse array of
observations in evolutionary genetics and molecular evolution and is thought to be a …
observations in evolutionary genetics and molecular evolution and is thought to be a …
Genome complexity, robustness and genetic interactions in digital organisms
Digital organisms are computer programs that self-replicate, mutate and adapt by natural
selection,,. They offer an opportunity to test generalizations about living systems that may …
selection,,. They offer an opportunity to test generalizations about living systems that may …
Mutation load: the fitness of individuals in populations where deleterious alleles are abundant
AF Agrawal, MC Whitlock - Annual Review of Ecology, Evolution …, 2012 - annualreviews.org
Many multicellular eukaryotes have reasonably high per-generation mutation rates.
Consequently, most populations harbor an abundance of segregating deleterious alleles …
Consequently, most populations harbor an abundance of segregating deleterious alleles …
The causes of epistasis
JAGM De Visser, TF Cooper… - Proceedings of the …, 2011 - royalsocietypublishing.org
Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …
The evolution of sex: empirical insights into the roles of epistasis and drift
JAGM De Visser, SF Elena - Nature Reviews Genetics, 2007 - nature.com
Despite many years of theoretical and experimental work, the explanation for why sex is so
common as a reproductive strategy continues to resist understanding. Recent empirical work …
common as a reproductive strategy continues to resist understanding. Recent empirical work …