Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Introduction: Despite recent advances in Alzheimer's disease (AD) research, no
breakthrough treatments have been discovered. Cholinesterase inhibitors and the NMDA …

Objective This study aimed to assess whether non‐invasive brain stimulation with
transcranial alternating current stimulation at gamma‐frequency (γ‐tACS) applied over the …

Serotonin (5-HT) plays an important role in the regulation of several basic functions of the
central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) …

Combination therapy involving different therapeutic strategies mostly provides more rapid
and effective results as compared to monotherapy in diverse areas of clinical practice. The …

Antagonism of the 5-HT 6 receptor is a promising approach for the symptomatic treatment of
Alzheimer's disease (AD). There is compelling preclinical evidence for the procognitive …

Effective treatments for neurodegenerative diseases remain elusive and are critically
needed since the burden of these diseases increases across an aging global population …

Degeneration of the cholinergic basal forebrain is implicated in the development of cognitive
deficits and sleep/wake architecture disturbances in mild cognitive impairment (MCI) and …

Cannabis sativa (Marijuana) has a long history as a medicinal plant and Δ9-
tetrahydrocannabinol (Δ9-THC) is the most active component in this plant. Cannabinoids are …

A new strategy in the design of aminergic GPCR ligands is proposed–the use of aromatic,
heterocyclic basic moieties in place of the evergreen piperazine or alicyclic and aliphatic …