Gabapentin and pregabalin are structurally related compounds with recognized efficacy in
the treatment of both epilepsy and neuropathic pain. The pharmacological mechanisms by …

A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

Gabapentin, a γ-aminobutyric acid (GABA) analogue anticonvulsant, is also an effective
analgesic agent in neuropathic and inflammatory, but not acute, pain systemically and …

Aims: Using primary cultures of mouse hippocampal neurons, we studied the molecular and
functional interactions between high mobility group box-1 (HMGB1) and the N-methyl-d …

Neuroprotection can be induced by low doses of NMDA, which activate both synaptic and
extrasynaptic NMDA receptors. This is in apparent contradiction with our recent findings that …

Many aspects of synaptic development, plasticity, and neurotransmission are critically
influenced by NMDAtype glutamate receptors (NMDARs). Moreover, dysfunction of …

Patients experiencing mental disorders are at an elevated risk for developing aggressive
behavior. In the past 10 years, the psychopharmacological treatment of aggression has …

WO2009021058A2 - Pharmaceutical compositions for treating chronic pain and pain
associated with neuropathy - Google Patents WO2009021058A2 - Pharmaceutical …

NMDA receptors (NMDARs) are glutamate-gated ion channels widely expressed in the
central nervous system (CNS) and endowed with unique biophysical, pharmacological and …

Despite the characteristic etiologies and phenotypes, different brain disorders rely on
common pathogenic events. Glutamate-induced neurotoxicity is a pathogenic event shared …