The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Mitochondrial network remodeling between fused and fragmented states facilitates
mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated …

Homeostasis of the gut microbiota critically influences host health and aging. Developing
genetically engineered probiotics holds great promise as a new therapeutic paradigm to …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Mitochondria are key players in aging and in the pathogenesis of age-related diseases.
Recent mitochondrial transcriptome analyses revealed the existence of multiple small …

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for
identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in
healthy individuals without diabetes. However, the metabolic response of a non-diabetic …