A transmembrane intracellular estrogen receptor mediates rapid cell signaling

CM Revankar, DF Cimino, LA Sklar, JB Arterburn… - Science, 2005 - science.org
The steroid hormone estrogen regulates many functionally unrelated processes in
numerous tissues. Although it is traditionally thought to control transcriptional activation …

Knowledge discovery and interactive data mining in bioinformatics-state-of-the-art, future challenges and research directions

A Holzinger, M Dehmer, I Jurisica - BMC bioinformatics, 2014 - Springer
Background The life sciences, biomedicine and health care are increasingly turning into a
data intensive science [2–4]. Particularly in bioinformatics and computational biology we …

High-throughput mapping of a dynamic signaling network in mammalian cells

M Barrios-Rodiles, KR Brown, B Ozdamar, R Bose… - Science, 2005 - science.org
Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for …

Molecular evidence of placental hypoxia in preeclampsia

N Soleymanlou, I Jurisica, O Nevo, F Ietta… - The Journal of …, 2005 - academic.oup.com
Background: Oxygen plays a central role in human placental pathologies including
preeclampsia, a leading cause of fetal and maternal death and morbidity. Insufficient …

Quantitative analysis of mammalian translation initiation sites by FACS‐seq

WL Noderer, RJ Flockhart, A Bhaduri… - Molecular systems …, 2014 - embopress.org
An approach combining fluorescence‐activated cell sorting and high‐throughput DNA
sequencing (FACS‐seq) was employed to determine the efficiency of start codon recognition …

Three-gene prognostic classifier for early-stage non–small-cell lung cancer

SK Lau, PC Boutros, M Pintilie, FH Blackhall… - Journal of Clinical …, 2007 - ascopubs.org
Purpose Several microarray studies have reported gene expression signatures that classify
non–small-cell lung carcinoma (NSCLC) patients into different prognostic groups. However …

Alterations in mitochondrial membrane potential during preimplantation stages of mouse and human embryo development

BM Acton, A Jurisicova, I Jurisica… - MHR: Basic science of …, 2004 - academic.oup.com
Mitochondria are cellular organelles regulating metabolism and cell death pathways. This
study examined changes in mitochondrial membrane potential (ΔΨm) throughout the stages …

From smart health to smart hospitals

A Holzinger, C Röcker, M Ziefle - Smart Health: Open Problems and Future …, 2015 - Springer
Prolonged life expectancy along with the increasing complexity of medicine and health
services raises health costs worldwide dramatically. Advancements in ubiquitous computing …

[HTML][HTML] From eHealth to iHealth: transition to participatory and personalized medicine in mental health

S Berrouiguet, MM Perez-Rodriguez, M Larsen… - Journal of medical …, 2018 - jmir.org
Clinical assessment in psychiatry is commonly based on findings from brief, regularly
scheduled in-person appointments. Although critically important, this approach reduces …

Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

AA Tone, H Begley, M Sharma, J Murphy, B Rosen… - Clinical cancer …, 2008 - AACR
Purpose: To identify molecular alterations potentially involved in predisposition to adnexal
serous carcinoma (SerCa) in the nonmalignant fallopian tube epithelium (FTE) of BRCA1/2 …