Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior.
Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and …

Phosphoinositides are membrane-bound signalling molecules that regulate cell proliferation
and survival, cytoskeletal reorganization and vesicular trafficking by recruiting effector …

Phagocytosis is an important component of innate and adaptive immunity. The formation of
phagosomes and the subsequent maturation that capacitates them for pathogen elimination …

Phosphoinositide phosphatases comprise several large enzyme families with over 35
mammalian enzymes identified to date that degrade many phosphoinositide signals. Growth …

BACKGROUND: Basophils are implicated in the pathogenesis of chronic idiopathic urticaria
(CIU). Autoantibodies to the IgE receptor (FcɛRI) and serum histamine releasing activity …

Ebselen, a multifunctional organoselenium compound, has been recognized as a potential
treatment for diabetes-related disorders. However, the underlying mechanisms whereby …

Phosphoinositide signalling molecules interact with a plethora of effector proteins to regulate
cell proliferation and survival, vesicular trafficking, metabolism, actin dynamics and many …

The specific interaction of phosphoinositides with proteins is critical for a plethora of cellular
processes, including cytoskeleton remodelling, mitogenic signalling, ion channel regulation …