Neuroplastic changes following brain ischemia and their contribution to stroke recovery: novel approaches in neurorehabilitation

C Alia, C Spalletti, S Lai, A Panarese… - Frontiers in cellular …, 2017 - frontiersin.org
Ischemic damage to the brain triggers substantial reorganization of spared areas and
pathways, which is associated with limited, spontaneous restoration of function. A better …

Filling the gaps on stroke research: Focus on inflammation and immunity

D Levard, I Buendia, A Lanquetin, M Glavan… - Brain, behavior, and …, 2021 - Elsevier
For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Short-chain fatty acids improve poststroke recovery via immunological mechanisms

R Sadler, JV Cramer, S Heindl, S Kostidis… - Journal of …, 2020 - Soc Neuroscience
Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …

Advanced neurotechnologies for the restoration of motor function

S Micera, M Caleo, C Chisari, FC Hummel, A Pedrocchi - Neuron, 2020 - cell.com
Stroke is one of the leading causes of long-term disability. Advanced technological solutions
(" neurotechnologies") exploiting robotic systems and electrodes that stimulate the nervous …

Task-specific modulation of corticospinal neuron activity during motor learning in mice

N Serradj, F Marino, Y Moreno-López… - Nature …, 2023 - nature.com
Motor skill learning relies on the plasticity of the primary motor cortex as task acquisition
drives cortical motor network remodeling. Large-scale cortical remodeling of evoked motor …

Cortical transplantation of brain‐mimetic glycosaminoglycan scaffolds and neural progenitor cells promotes vascular regeneration and functional recovery after …

MR McCrary, K Jesson, ZZ Wei… - Advanced …, 2020 - Wiley Online Library
Stroke causes significant mortality and morbidity. Currently, there are no treatments which
can regenerate brain tissue lost to infarction. Neural progenitor cells (NPCs) are at the …

Artery targeted photothrombosis widens the vascular penumbra, instigates peri-infarct neovascularization and models forelimb impairments

TA Clark, C Sullender, SM Kazmi, BL Speetles… - Scientific reports, 2019 - nature.com
The photothrombotic stroke model generates localized and reproducible ischemic infarcts
that are useful for studying recovery mechanisms, but its failure to produce a substantial …

Automated home cage training of mice in a hold-still center-out reach task

T Bollu, SC Whitehead, N Prasad… - Journal of …, 2019 - journals.physiology.org
An obstacle to understanding neural mechanisms of movement is the complex, distributed
nature of the mammalian motor system. Here we present a novel behavioral paradigm for …

The tactile experience paired with vagus nerve stimulation determines the degree of sensory recovery after chronic nerve damage

MJ Darrow, TM Mian, M Torres, Z Haider… - Behavioural brain …, 2021 - Elsevier
Loss of sensory function is a common consequence of neurological injury. Recent clinical
and preclinical evidence indicates vagus nerve stimulation (VNS) paired with tactile …

High-throughput automatic training system for odor-based learned behaviors in head-fixed mice

Z Han, X Zhang, J Zhu, Y Chen, CT Li - Frontiers in neural circuits, 2018 - frontiersin.org
Understanding neuronal mechanisms of learned behaviors requires efficient behavioral
assays. We designed a high-throughput automatic training system (HATS) for olfactory …