Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …

De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …

Mitochondria are dynamic organelles that function in cellular energy metabolism,
intracellular and extracellular signalling, cellular fate and stress responses. Mitochondria of …

Canonical WNT signaling is an important developmental pathway that has attracted
increased attention for anticancer drug discovery. From the production and secretion of WNT …

Cervical cancer is one of the most common female malignant tumors, with typical cancer
metabolism characteristics of increased glycolysis flux and lactate accumulation. 2‐Deoxy‐D …

Cancer cells undergo significant “metabolic remodeling” to provide sufficient ATP to
maintain cell survival and to promote rapid growth. In colorectal cancer cells, ATP is …

Regulatory T cells (Tregs) are essential to maintain self-tolerance and immune homeostasis
but, as components of the tumor microenvironment (TME), are also a major barrier to …

Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis
Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a …

Background: Alzheimer's disease (AD) is characterized by a high etiological and clinical
heterogeneity, which has obscured the diagnostic and treatment efficacy, as well as limited …

The Wnt/β-catenin pathway's significance in cancer initiation, progression, and stem cell
biology underscores its therapeutic potential. However, the clinical application of Wnt …