The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over
motivated behavior, feeding, and energy balance across species. Recent single-cell …

The parabrachial nucleus (PBN) is a major hub that receives sensory information from both
internal and external environments. Specific populations of PBN neurons are involved in …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

The neurotensin system spans across the central nervous system, to the enteric nervous
system (gut), and the periphery to govern behaviors and physiological responses that tune …

Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb)
drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal …

The brain's ability to associate threats with external stimuli is vital to execute essential
behaviours including avoidance. Disruption of this process contributes instead to the …

Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …

In vivo fluorescence recording techniques have produced landmark discoveries in
neuroscience, providing insight into how single cell and circuit-level computations mediate …

Our recent study demonstrated the critical role of the mesolimbic dopamine (DA) circuit and
its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The …