The extracellular matrix represents a complex alloy of variable members of diverse protein
families defining structural integrity and various physiological functions. The most abundant …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

Multipotent stem cells that generate both neurons and glia are widespread components of
the early neuroepithelium. During CNS development, neurogenesis largely precedes …

During development, basic helix–loop–helix (bHLH) proteins regulate formation of neurons
from multipotent progenitor cells. However, bHLH factors linked to gliogenesis have not …

Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans.
Some of the proteoglycans have distinct core protein structures, and others display …

The diverse functions of glial cells prompt the question to which extent specific subtypes may
be devoted to a specific function. We discuss this by reviewing one of the most recently …

We developed a method to extract differentially chondroitin sulfate proteoglycans (CSPGs)
that are diffusely present in the central nervous system (CNS) matrix and CSPGs that are …

Oligodendrocytes, myelin-forming glial cells of the central nervous system, are vulnerable to
damage in a variety of neurologic diseases. Much is known of primary myelin injury, which …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …