Scarring and tissue fibrosis represent a significant source of morbidity in the United States.
Despite considerable research focused on elucidating the mechanisms underlying …

Human skin is a highly specialized mechanoresponsive interface separating our bodies
from the external environment. It must constantly adapt to dynamic physical cues ranging …

Keloids tend to occur on highly mobile sites with high tension. This study was designed to
determine whether body surface areas exposed to large strain during normal activities …

Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result
from abnormal healing of injured or irritated skin. They can be called pathological or …

Cutaneous wound healing is a complex process with many types of mechanical forces
regulating the quality and speed of healing. The role of mechanical forces in regulating …

We use evidence-based algorithms to treat abnormal scarring, including keloids and
hypertrophic scars (HSs). This involves a multimodal approach that employs traditional …

The mechanophysiological conditions of injured skin greatly influence the degree of scar
formation, scar contracture, and abnormal scar progression/generation (eg, keloids and …

Scarring is a major clinical issue that affects a considerable number of patients. The
associated problems go beyond the loss of skin functionality, as scars bring aesthetic …

Recent evidence suggests that mechanical forces can significantly impact the biologic
response to injury. Integrated mechanical and chemical signaling networks have been …

Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the
adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but …