Mechanotransduction and fibrosis
Scarring and tissue fibrosis represent a significant source of morbidity in the United States.
Despite considerable research focused on elucidating the mechanisms underlying …
Despite considerable research focused on elucidating the mechanisms underlying …
[HTML][HTML] Pushing back: wound mechanotransduction in repair and regeneration
VW Wong, S Akaishi, MT Longaker… - Journal of Investigative …, 2011 - Elsevier
Human skin is a highly specialized mechanoresponsive interface separating our bodies
from the external environment. It must constantly adapt to dynamic physical cues ranging …
from the external environment. It must constantly adapt to dynamic physical cues ranging …
The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation
R Ogawa, K Okai, F Tokumura, K Mori… - Wound Repair and …, 2012 - Wiley Online Library
Keloids tend to occur on highly mobile sites with high tension. This study was designed to
determine whether body surface areas exposed to large strain during normal activities …
determine whether body surface areas exposed to large strain during normal activities …
[HTML][HTML] Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis–keloids and hypertrophic scars may be vascular disorders
R Ogawa, S Akaishi - Medical Hypotheses, 2016 - Elsevier
Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result
from abnormal healing of injured or irritated skin. They can be called pathological or …
from abnormal healing of injured or irritated skin. They can be called pathological or …
A review of the role of mechanical forces in cutaneous wound healing
R Agha, R Ogawa, G Pietramaggiori… - Journal of Surgical …, 2011 - Elsevier
Cutaneous wound healing is a complex process with many types of mechanical forces
regulating the quality and speed of healing. The role of mechanical forces in regulating …
regulating the quality and speed of healing. The role of mechanical forces in regulating …
Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile …
R Ogawa, S Akaishi, C Huang, T Dohi… - Journal of Nippon …, 2011 - jstage.jst.go.jp
We use evidence-based algorithms to treat abnormal scarring, including keloids and
hypertrophic scars (HSs). This involves a multimodal approach that employs traditional …
hypertrophic scars (HSs). This involves a multimodal approach that employs traditional …
Mechanobiology of scarring
R Ogawa - Wound Repair and Regeneration, 2011 - Wiley Online Library
The mechanophysiological conditions of injured skin greatly influence the degree of scar
formation, scar contracture, and abnormal scar progression/generation (eg, keloids and …
formation, scar contracture, and abnormal scar progression/generation (eg, keloids and …
[HTML][HTML] Mechanomodulatory biomaterials prospects in scar prevention and treatment
Scarring is a major clinical issue that affects a considerable number of patients. The
associated problems go beyond the loss of skin functionality, as scars bring aesthetic …
associated problems go beyond the loss of skin functionality, as scars bring aesthetic …
Soft tissue mechanotransduction in wound healing and fibrosis
VW Wong, MT Longaker, GC Gurtner - Seminars in cell & developmental …, 2012 - Elsevier
Recent evidence suggests that mechanical forces can significantly impact the biologic
response to injury. Integrated mechanical and chemical signaling networks have been …
response to injury. Integrated mechanical and chemical signaling networks have been …
Systemic factors that shape cutaneous pathological scarring
C Huang, R Ogawa - The FASEB Journal, 2020 - Wiley Online Library
Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the
adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but …
adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but …