Tumour fatty acid metabolism in the context of therapy resistance and obesity
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
[HTML][HTML] Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation
C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …
and proliferation. These metabolic alterations include (1) a shift from oxidative …
[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
[HTML][HTML] Prognosis and dissection of immunosuppressive microenvironment in breast cancer based on fatty acid metabolism-related signature
Fatty acid metabolism has been deciphered to augment tumorigenesis and disease
progression in addition to therapy resistance via strengthened lipid synthesis, storage, and …
progression in addition to therapy resistance via strengthened lipid synthesis, storage, and …
[HTML][HTML] Mitochondria in cancer
D Grasso, LX Zampieri, T Capelôa, JA Van de Velde… - Cell stress, 2020 - ncbi.nlm.nih.gov
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
[HTML][HTML] Oncogenic pathways and the electron transport chain: a dangeROS liaison
Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
[HTML][HTML] Mitochondrial CPT1A: Insights into structure, function, and basis for drug development
K Liang - Frontiers in pharmacology, 2023 - frontiersin.org
Carnitine Palmitoyl-Transferase1A (CPT1A) is the rate-limiting enzyme in the fatty acid β-
oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic …
oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic …
[HTML][HTML] Reprogramming of lipid metabolism in lung cancer: An overview with focus on EGFR-Mutated non-small cell lung cancer
K Eltayeb, S La Monica, M Tiseo, R Alfieri, C Fumarola - Cells, 2022 - mdpi.com
Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …
[HTML][HTML] Lipid metabolism and endocrine resistance in prostate cancer, and new opportunities for therapy
GE Stoykova, IR Schlaepfer - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men, and more than 10% of men will
be diagnosed with PCa during their lifetime. Patients that are not cured with surgery or …
be diagnosed with PCa during their lifetime. Patients that are not cured with surgery or …
Too complex to fail? Targeting fatty acid metabolism for cancer therapy
Given the central role of fatty acids in cancer pathophysiology, the exploitation of fatty acid
metabolism as a potential antineoplastic therapy has gained much attention. Several natural …
metabolism as a potential antineoplastic therapy has gained much attention. Several natural …