[HTML][HTML] Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

U Sengupta, R Kayed - Progress in neurobiology, 2022 - Elsevier
Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

The gut–brain axis and its relation to Parkinson's disease: a review

EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies

P Magalhães, HA Lashuel - npj Parkinson's Disease, 2022 - nature.com
Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disease, develops and progresses for 10–15 years before the clinical …

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Staging of Alzheimer's disease: past, present, and future perspectives

J Therriault, ER Zimmer, AL Benedet… - Trends in molecular …, 2022 - cell.com
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

The prion-like spreading of alpha-synuclein in Parkinson's disease: update on models and hypotheses

A Jan, NP Gonçalves, CB Vaegter, PH Jensen… - International journal of …, 2021 - mdpi.com
The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Biomarkers for Parkinson's disease: how good are they?

T Li, W Le - Neuroscience bulletin, 2020 - Springer
Parkinson's disease (PD) is a complex neurodegenerative disorder with no cure in sight.
Clinical challenges of the disease include the inability to make a definitive diagnosis at the …

Update on CSF biomarkers in Parkinson's disease

EH Kwon, S Tennagels, R Gold, K Gerwert, L Beyer… - Biomolecules, 2022 - mdpi.com
Progress in developing disease-modifying therapies in Parkinson's disease (PD) can only
be achieved through reliable objective markers that help to identify subjects at risk. This …

Biomarkers in Parkinson's disease

A Surguchov - … diseases biomarkers: Towards translating research to …, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …

Selective autophagy as a therapeutic target for neurological diseases

W Xu, U Ocak, L Gao, S Tu, CJ Lenahan… - Cellular and Molecular …, 2021 - Springer
The neurological diseases primarily include acute injuries, chronic neurodegeneration, and
others (eg, infectious diseases of the central nervous system). Autophagy is a housekeeping …