Microfluidics has become a mature technology, providing an excellent toolbox for the
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

Organ on chip (OoC) devices represent the cutting edge of biotechnologies, combining
advanced cell and tissue culture with microengineering. OoC is accelerating innovation in …

Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …

Microfluidic organ-on-a-chip (Organ Chip) cell culture devices are often fabricated using
polydimethylsiloxane (PDMS) because it is biocompatible, transparent, elastomeric, and …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …

Microfluidics has been widely used in biological, chemical, medical and environmental fields
for the precise control of liquid in micro/nanoscale. Various fabrication methods have been …

Insulin is released from pancreatic islets in a biphasic and pulsatile manner in response to
elevated glucose levels. This highly dynamic insulin release can be studied in vitro with islet …