Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical
modification of proteins. Both chemical and biological innovations made possible by …

Dehydroalanine is a synthetic precursor to a wide array of protein modifications. We
describe multiple methods for the chemical conversion of cysteine to dehydroalanine on …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

It is becoming ever clearer that the presence of carbohydrate units in naturally occurring
structures and their mimetics has a dramatic effect on their physical, chemical, and biological …

Over half of all proteins in nature are estimated to be glycosylated,[1] and these
biomolecules play key roles in protein expression, folding and stability [2–7] and are …

Low cost and simplicity of cultivating bacteria make the E. coli expression system a
preferable choice for production of therapeutic proteins both on a lab scale and in industry …

Glycoproteins are an important class of biomolecules involved in a number of biological
recognition processes. However, natural and recombinant glycoproteins are usually …

Oligosaccharides on proteins and lipids play central roles in human health and disease. The
molecular analysis of glycoconjugate function has benefited tremendously from new …