Peptides as a therapeutic strategy against Klebsiella pneumoniae

CM de Souza, ÁP da Silva, NGO Júnior… - Trends in …, 2022 - cell.com
Increasing levels of resistance to conventional antibiotics have led to a search for new
therapeutic options against bacterial infections. Klebsiella pneumoniae is considered a …

Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review

AM de Souza Nascimento… - Journal of Enzyme …, 2022 - Taylor & Francis
This systematic review (SR) aimed to gather studies describing the antibacterial action
mechanisms and mode of trypsin inhibitors. The review protocol was registered …

[HTML][HTML] Prevention of hospital pathogen biofilm formation by antimicrobial peptide KWI18

LS Lima, SR Ramalho, GC Sandim, EB Parisotto… - Microbial …, 2022 - Elsevier
This study investigated the antimicrobial and antibiofilm activity of KWI18, a new synthetic
peptide. KWI18 was tested against planktonic cells and Pseudomonas aeruginosa and …

[HTML][HTML] A new bioinspired peptide on defensin from C. annuum fruits: Antimicrobial activity, mechanisms of action and therapeutical potential

GB Taveira, É de Oliveira Mello, TLBV Simão… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Background Antimicrobial peptides, natural or synthetic, appear as promising molecules for
antimicrobial therapy because of their both broad antimicrobial activity and mechanism of …

Potent Anti-Candida Fraction Isolated from Capsicum chinense Fruits Contains an Antimicrobial Peptide That is Similar to Plant Defensin and is Able to Inhibit the …

MCL Aguieiras, LM Resende, TAM Souza… - Probiotics and …, 2021 - Springer
Antimicrobial peptides (AMPs) are molecules present in several life forms, possess broad-
spectrum of inhibitory activity against pathogenic microorganisms, and are a promising …

Prospecting in silico antibacterial activity of a peptide from trypsin inhibitor isolated from tamarind seed

GS Oliveira, AMS Nascimento, ABS Luz… - Journal of Enzyme …, 2023 - Taylor & Francis
Bacterial infections have become a global concern, stimulating the growing demand for
natural and biologically safe therapeutic agents with antibacterial action. This study was …

The synthetic antimicrobial peptide IKR18 displays anti-infectious properties in Galleria mellonella in vivo model

SR Ramalho, JCO Sardi, EC Júnior, R Marchetto… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Antimicrobial peptides (AMPs) are promising tools for developing new antibiotics. We
described the design of IKR18, an AMP designed with the aid of computational tools. IKR18 …

Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review

MG Parisi, B Ozón, SM Vera González, J García-Pardo… - Pharmaceutics, 2024 - mdpi.com
Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense
mechanisms in a wide range of living organisms, including bacteria, mammals, and plants …

Computer-made peptide RQ18 acts as a dual antifungal and antibiofilm peptide though membrane-associated mechanisms of action

CV Almeida, CFR de Oliveira… - Archives of Biochemistry …, 2024 - Elsevier
The spread of fungi resistant to conventional drugs has become a threatening problem. In
this context, antimicrobial peptides (AMPs) have been considered as one of the main …

Boosting the antibacterial potential of a linear encrypted peptide in a Kunitz-type inhibitor (ApTI) through physicochemical-guided approaches

C de Oliveira Gutierrez, LH de Oliveira Almeida… - Biochimie, 2024 - Elsevier
Bacterial resistance has become a serious public health problem in recent years, thus
encouraging the search for new antimicrobial agents. Here, we report an antimicrobial …