Reverse transcription and integration are the defining features of the Retroviridae; the
common name “retrovirus” derives from the fact that these viruses use a virally encoded …

The rapid replication of HIV-1 and the errors made during viral replication cause the virus to
evolve rapidly in patients, making the problems of vaccine development and drug therapy …

Retroviral DNA integration involves a coordinated set of DNA cutting and jolning reactions.
Linear viral DNA is cleaved at each 3'end to generate the precursor ends for integration. The …

HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …

All presently available replication-competent proviral clones of human immunodeficiency
virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is …

Efficient retroviral growth requires integration of a DNA copy of the viral RNA genome into a
chromosome of the host. As a first step in analyzing the mechanism of integration of human …

Growth of human immunodeficiency virus (HIV) after infection requires the integration of a
DNA copy of the viral RNA genome into a chromosome of the host. Here we present a …

Proteolytic enzymes have many physiological functions in plants, bacteria, viruses, protozoa
and mammals. They play a role in processes such as food digestion, complement activation …

Reverse transcriptases (RTs) play a major role in the replication of Retroviridae,
Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are …