Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

This review summarizes the recent knowledge on the effects of dietary carbohydrates and
lipids on the pathophysiology of leaky gut syndrome (LGS). Alterations in intestinal barrier …

Lipids are essential structural and functional components of the central nervous system
(CNS). Sphingolipids are ubiquitous membrane components which were discovered in the …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

Stroke is a prevalent cerebrovascular condition with a global impact, causing significant
rates of illness and death. Despite extensive research, the available treatment options for …

Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

In spite of advances in vaccination, control of the COVID-19 pandemic will require the use of
pharmacological treatments against SARS-CoV2. Their development needs to consider the …

Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …