The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Drosophila olfaction: past, present and future

R Benton - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Among the many wonders of nature, the sense of smell of the fly Drosophila melanogaster
might seem, at first glance, of esoteric interest. Nevertheless, for over a century, the 'nose'of …

The connectome of the adult Drosophila mushroom body provides insights into function

F Li, JW Lindsey, EC Marin, N Otto, M Dreher… - Elife, 2020 - elifesciences.org
Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways

A Zolin, R Cohn, R Pang, AF Siliciano, AL Fairhall… - Nature …, 2021 - nature.com
Dopamine plays a central role in motivating and modifying behavior, serving to invigorate
current behavioral performance and guide future actions through learning. Here we examine …

Complete connectomic reconstruction of olfactory projection neurons in the fly brain

AS Bates, P Schlegel, RJV Roberts, N Drummond… - Current Biology, 2020 - cell.com
Nervous systems contain sensory neurons, local neurons, projection neurons, and motor
neurons. To understand how these building blocks form whole circuits, we must distil these …

Information flow, cell types and stereotypy in a full olfactory connectome

P Schlegel, AS Bates, T Stürner, SR Jagannathan… - Elife, 2021 - elifesciences.org
The hemibrain connectome provides large-scale connectivity and morphology information
for the majority of the central brain of Drosophila melanogaster. Using this data set, we …

Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

S Aimon, KY Cheng, J Gjorgjieva, ICG Kadow - Elife, 2023 - elifesciences.org
Movement-correlated brain activity has been found across species and brain regions. Here,
we used fast whole brain lightfield imaging in adult Drosophila to investigate the relationship …

Dopaminergic systems create reward seeking despite adverse consequences

KD Jovanoski, L Duquenoy, J Mitchell, I Kapoor… - Nature, 2023 - nature.com
Resource-seeking behaviours are ordinarily constrained by physiological needs and threats
of danger, and the loss of these controls is associated with pathological reward seeking …

A neural circuit for wind-guided olfactory navigation

AMM Matheson, AJ Lanz, AM Medina, AM Licata… - Nature …, 2022 - nature.com
To navigate towards a food source, animals frequently combine odor cues about source
identity with wind direction cues about source location. Where and how these two cues are …

Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster

N Eckstein, AS Bates, A Champion, M Du, Y Yin… - Cell, 2024 - cell.com
High-resolution electron microscopy of nervous systems has enabled the reconstruction of
synaptic connectomes. However, we do not know the synaptic sign for each connection (ie …