Mitochondrial functionality in male fertility: from spermatogenesis to fertilization

YJ Park, MG Pang - Antioxidants, 2021 - mdpi.com
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Spermatogenesis in humans and its affecting factors

FTL Neto, PV Bach, BB Najari, PS Li… - Seminars in cell & …, 2016 - Elsevier
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Bisphenol A (BPA) and cell signaling pathways

M Murata, JH Kang - Biotechnology advances, 2018 - Elsevier
Abstract Bisphenol A (BPA; 4, 4′-isopropylidenediphenol) is an endocrine disruptor that is
used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy …

Mitochondria quality control and male fertility

J Costa, PC Braga, I Rebelo, PF Oliveira, MG Alves - Biology, 2023 - mdpi.com
Simple Summary Mitochondria play a crucial role in numerous cellular processes, including
energy production, apoptosis, and calcium homeostasis. In the male reproductive system …

Spermatogenesis

H Nishimura, SW L'Hernault - Current Biology, 2017 - cell.com
Most organisms consist of two cell lineages—somatic cells and germ cells. The former are
required for the current generation, and the latter create offspring. Male and female germ …

[HTML][HTML] Etiologies of sperm oxidative stress

P Sabeti, S Pourmasumi, T Rahiminia… - International Journal …, 2016 - ncbi.nlm.nih.gov
Sperm is particularly susceptible to reactive oxygen species (ROS) during critical phases of
spermiogenesis. However, the level of seminal ROS is restricted by seminal antioxidants …

Dichloroacetate and cancer: new home for an orphan drug?

S Kankotia, PW Stacpoole - Biochimica et Biophysica Acta (BBA)-Reviews …, 2014 - Elsevier
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational
treatment for various acquired and congenital disorders of mitochondrial intermediary …

[HTML][HTML] MicroRNAs and spermatogenesis

N Kotaja - Fertility and sterility, 2014 - Elsevier
In mammals, male gametes are produced inside the testis by spermatogenesis, which has
three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid …

Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function

RC Edenfield, CA Easley IV - Nature Reviews Urology, 2022 - nature.com
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively
little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection …

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

MG Alves, L Rato, RA Carvalho, PI Moreira… - Cellular and molecular …, 2013 - Springer
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …