Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …

To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

We developed a new way to engineer complex proteins toward multidimensional
specifications using a simple, yet scalable, directed evolution strategy. By robotically picking …

Cell-type-specific expression of molecular tools and sensors is critical to construct circuit
diagrams and to investigate the activity and function of neurons within the nervous system …

Spatially charting molecular cell types at single-cell resolution across the 3D volume is
critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA …

Recombinant Adeno-associated virus vectors (rAAV) are widely used for gene delivery and
multiple naturally occurring serotypes have been harnessed to target cells in different …

Structural, biochemical and biophysical studies of eukaryotic soluble and membrane
proteins require their production in milligram quantities. Although large-scale protein …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

ABSTRACT Infectious coronavirus (CoV) disease 2019 (COVID-19) emerged in the city of
Wuhan (China) in December 2019, causing a pandemic that has dramatically impacted …