The clinical manifestations of amyotrophic lateral sclerosis (ALS) are variable in terms of age
at disease onset, site of onset, progression of symptoms, motor neuron involvement, and the …

Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by gradual loss of upper and lower motor neurons and their pathways, usually …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets the
motor system. Although much is known about the effects of ALS on motor neurons and glial …

Emerging studies corroborate the importance of neuroimaging biomarkers and machine
learning to improve diagnostic classification of amyotrophic lateral sclerosis (ALS). While …

The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients
show structural changes within but also beyond the motor cortex and corticospinal tract and …

Introduction The majority of imaging studies in ALS infer group-level imaging signatures
from group comparisons, as opposed to estimating disease burden in individual patients. In …

Amyotrophic lateral sclerosis (ALS) is a rare degenerative disorder characterized by loss of
upper and lower motor neurons. Neuroimaging has provided noticeable evidence that ALS …

An objective biomarker for early identification and accurate differential diagnosis of
amyotrophic lateral sclerosis (ALS) is lacking. 18F-FDG PET brain imaging with advanced …