Application of proteomics in cancer: recent trends and approaches for biomarkers discovery

YW Kwon, HS Jo, S Bae, Y Seo, P Song, M Song… - Frontiers in …, 2021 - frontiersin.org
Proteomics has become an important field in molecular sciences, as it provides valuable
information on the identity, expression levels, and modification of proteins. For example …

The role of extracellular vesicles in the hallmarks of cancer and drug resistance

CPR Xavier, HR Caires, MAG Barbosa, R Bergantim… - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …

[HTML][HTML] Extracellular heat shock proteins and cancer: New perspectives

Z Albakova, MKS Siam, PK Sacitharan… - Translational …, 2021 - Elsevier
Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly
expressed in cancer. The expression of HSPs in tumor cells has been shown to be …

Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis

S Ebrahimkhani, F Vafaee, S Hallal, H Wei… - NPJ precision …, 2018 - nature.com
Exosomes are nano-sized extracellular vesicles released by many cells that contain
molecules characteristic of their cell of origin, including microRNA. Exosomes released by …

Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis

AB Ghaemmaghami, M Mahjoubin-Tehran… - Cell Communication and …, 2020 - Springer
Malignant gliomas are the most common and deadly type of central nervous system tumors.
Despite some advances in treatment, the mean survival time remains only about 1.25 years …

CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway

Y Li, C Liu, X Zhang, X Huang, S Liang, F Xing… - British Journal of …, 2022 - nature.com
Background Lymph node (LN) metastasis confers gastric cancer (GC) progression, poor
survival and cancer-related death. Aberrant activation of Wnt/β-catenin promotes epithelial …

Latest advances in extracellular vesicles: from bench to bedside

T Yamamoto, N Kosaka, T Ochiya - Science and Technology of …, 2019 - Taylor & Francis
Extracellular vesicles (EVs) are small membraned vesicles and approximately 50–150 nm in
diameter. Almost all of the type of cells releases the EVs and circulates in the body fluids …

Glioblastoma biomarkers in urinary extracellular vesicles reveal the potential for a 'liquid gold'biopsy

SM Hallal, Á Tűzesi, LA Sida, E Xian, D Madani… - British Journal of …, 2024 - nature.com
Background Biomarkers that reflect glioblastoma tumour activity and treatment response are
urgently needed to help guide clinical management, particularly for recurrent disease. As the …

The TRiCky business of protein folding in health and disease

H Ghozlan, A Cox, D Nierenberg, S King… - Frontiers in Cell and …, 2022 - frontiersin.org
Maintenance of the cellular proteome or proteostasis is an essential process that when
deregulated leads to diseases like neurological disorders and cancer. Central to …

Extracellular vesicles and their role in glioblastoma

CA Whitehead, AH Kaye, KJ Drummond… - Critical Reviews in …, 2020 - Taylor & Francis
Research on the role of extracellular vesicles (EVs) in disease pathogenesis has been
rapidly growing over the last two decades. As EVs can mediate intercellular communication …