Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Conversion of tryptophan to N-formylkynurenine is the first and rate-limiting step of the
tryptophan metabolic pathway (ie, the kynurenine pathway). This conversion is catalyzed by …

Background and Objectives: The aim of this systematic review was to analyse which
candidate genes were examined in genetic association studies and their association with …

Agomelatine (AGM) is one of the latest atypical antidepressants, prescribed exclusively for
the treatment of depression in adults. AGM belongs to the pharmaceutical class of melatonin …

Antidepressant therapy is still associated with delays in symptomatic improvement and low
response rates. Incomplete understanding of molecular mechanisms underlying …

Abstract Zinc Oxide nanoparticles (ZnO NPs) have dualistic properties due to their
advantage and toxicity. However, the impact and mechanisms of ZnO NPs on the prefrontal …

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of
several pathological conditions, especially cancers. Here we present the synthesis of a …

A growing body of evidence suggests that depression may be associated with impairment of
the tryptophan catabolites (TRYCATs) pathway. The present study investigated the effects of …

Single-nucleotide polymorphisms (SNPs) of the IDO1 and IDO2 genes have been
associated with some diseases. Here, we investigated the association of IDO1 and IDO2 …

Ischemic stroke is among the leading causes of mortality and long-term disability worldwide.
Among stroke risk factors the importance of genetic background is gaining interest. There is …