Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

▪ Abstract Biochemical and genetic approaches have identified the molecular mechanisms
of many genetic reactions, particularly in bacteria. Now a comparably detailed …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

The two main contributions of this article are the solidification of Corynebacterium
glutamicum biochemistry guided by bioreaction network analysis, and the determination of …

Despite extensive study of individual enzymes and their organization into pathways, the
means by which enzyme networks control metabolite concentrations and fluxes in cells …

We show how the phenomena of genetic dominance, overdominance, additivity, and
epistasis are generic features of simple diploid gene regulatory networks. These regulatory …

This paper concerns oscillations arising in a sequence of biochemical reactions S 0→ S
1↓→ S 2↓→⋯→ S n→ whose end-product inhibits the rate of the first reaction. Except for …

Biochemical systems are among of the oldest application areas of mathematical modeling.
Spanning a time period of over one hundred years, the repertoire of options for structuring a …

As of yet, steady‐state optimization in biochemical systems has been limited to a few studies
in which networks of fluxes were optimized. These networks of fluxes are represented by …

Experimental and clinical data on purine metabolism are collated and analyzed with three
mathematical models. The first model is the result of an attempt to construct a traditional …