Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …

TGFβ1 has been implicated in regulating functional aspects of several distinct immune cell
populations including central nervous system (CNS) resident microglia. Activation and …

In recent years, a growing body of research has shown sex differences in the prevalence
and symptomatology of psychopathologies, such as depression, anxiety, and fear-related …

Sexual differentiation of the brain during early development likely underlies the strong sex
biases prevalent in many neurological conditions. Mounting evidence indicates that …

Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …

Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Sex plays a role in the incidence and outcome of neurological illnesses, also influencing the
response to treatments. Despite sexual differentiation of the brain has been extensively …