Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles in vaccine development

A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

A cornucopia of human polyomaviruses

JA DeCaprio, RL Garcea - Nature reviews Microbiology, 2013 - nature.com
During the past 6 years, focused virus hunting has led to the discovery of nine new human
polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell …

Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles

RC Rose, W Bonnez, RC Reichman… - Journal of virology, 1993 - Am Soc Microbiol
The L1 coat protein of human papillomavirus type 11 (HPV-11) was expressed in Sf-9 insect
cells with the recombinant baculovirus vector Ac11L1. Viruslike particles (VLPs) were …

The structure of simian virus 40 refined at 3.1 Å resolution

T Stehle, SJ Gamblin, Y Yan, SC Harrison - Structure, 1996 - cell.com
Background: The structure of simian virus 40 (SV40), previously determined at 3.8 å
resolution, shows how its pentameric VP1 assembly units are tied together by extended C …

Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model

HL Greenstone, JD Nieland… - Proceedings of the …, 1998 - National Acad Sciences
Papillomavirus-like particles (VLPs) are a promising prophylactic vaccine candidate to
prevent human papillomavirus (HPV) infections and associated epithelial neoplasia …

[HTML][HTML] Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry

XS Chen, T Stehle, SC Harrison - The EMBO journal, 1998 - embopress.org
A complex of the polyomavirus internal protein VP2/VP3 with the pentameric major capsid
protein VP1 has been prepared by co‐expression in Escherichia coli. AC‐terminal segment …

Expression of foreign genes in insect cells using baculovirus vectors

S Maeda - Insect cell biotechnology, 2018 - taylorfrancis.com
This chapter emphasizes recent progress in the use of baculovirus expression vectors,
especially in regard to applications in agriculture and medicine, and outlines the …

Viruses and their uses in nanotechnology

P Singh, MJ Gonzalez… - Drug development …, 2006 - Wiley Online Library
The use of materials derived from natural sources in materials science has allowed the
harnessing of complex structures resulting from eons of evolutionary fine‐tuning. A better …