Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

The azetidinone core-structure offers a unique approach to the design and synthesis of new
derivatives with unique biological properties. During the last two decades researches …

Phytopathogenic fungal infections have become a major threat to agricultural production,
food security, and human health globally, and novel antifungal agents with simple chemical …

Twelve novel 8-hydroxyquinoline derivatives were synthesized with good yields by
performing copper-catalyzed Huisgen 1, 3-dipolar cycloaddition (“click” reaction) between …

A new series of 2, 5 and 1, 5-regioisomers of the tetrazolyl group viz., 3-[(5-benzyl/benzylthio-
2H-tetrazol-2-yl) methyl]-2-chloro-6-substituted quinoline 6h-q and 3-[(5-benzyl/benzylthio …

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic
agents; however, the development of multidrug resistance has limited their clinical activity …

Matrix metalloproteinases (MMPs) play important roles in many diseases including cancer.
With moderate metal-binding affinity, 8-hydroxyquinoline has gained much interest in current …

Phytopathogenic fungi have become a serious threat to the quality of agricultural products,
food security and human health globally, necessitating the need to discover new antifungal …

Schistosomiasis remains one of the most prevalent parasitic infections and has significant
public health consequences. Praziquantel (PZQ) is the only drug currently administrated to …

A series of 4-oxycoumarin derivatives was synthesized, characterized and evaluated in vitro
and in vivo for antifilarial activity against the human lymphatic filarial parasite, Brugia malayi …