[HTML][HTML] 1, 2, 4-Triazoles as important antibacterial agents
M Strzelecka, P Świątek - Pharmaceuticals, 2021 - mdpi.com
The global spread of drug resistance in bacteria requires new potent and safe antimicrobial
agents. Compounds containing the 1, 2, 4-triazole ring in their structure are characterised by …
agents. Compounds containing the 1, 2, 4-triazole ring in their structure are characterised by …
Advances in the application of 1, 2, 4-triazole-containing hybrids as anti-tuberculosis agents
Y Cao, H Lu - Future Medicinal Chemistry, 2021 - Taylor & Francis
Tuberculosis is a deadly communicable disease caused by the bacillus Mycobacterium
tuberculosis (MTB), and pulmonary tuberculosis accounts for over 80% of the total cases …
tuberculosis (MTB), and pulmonary tuberculosis accounts for over 80% of the total cases …
[HTML][HTML] New application of 1, 2, 4-triazole derivatives as antitubercular agents. Structure, in vitro screening and docking studies
Z Karczmarzyk, M Swatko-Ossor, W Wysocki, M Drozd… - Molecules, 2020 - mdpi.com
A series of 1, 2, 4-triazole derivatives were synthesized and assigned as potential anti-
tuberculosis substances. The molecular and crystal structures for the model compounds C1 …
tuberculosis substances. The molecular and crystal structures for the model compounds C1 …
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction
derivatives that were screened for their antimicrobial activity and compared them with …
derivatives that were screened for their antimicrobial activity and compared them with …
[HTML][HTML] Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular …
KN Venugopala, M Kandeel, M Pillay, PK Deb… - Antibiotics, 2020 - mdpi.com
In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4
H-1, 2, 4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were subjected to whole-cell anti …
H-1, 2, 4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were subjected to whole-cell anti …
From Phenylhydrazone to 1H‐1,2,4‐Triazoles via Nitrification, Reduction and Cyclization
L Hao, G Wang, J Sun, J Xu, H Li… - Advanced Synthesis …, 2020 - Wiley Online Library
Herein we report an annulation of phenylhydrazone via a tandem nitrification, reduction,
cyclization protocol employing cobalt nitrate and 1, 2‐dichloroethane to produce substituted …
cyclization protocol employing cobalt nitrate and 1, 2‐dichloroethane to produce substituted …
Oxazolyl-pyrimidines as antibacterial and antitubercular agents: synthesis, biological evaluation, in-silico ADMET and molecular docking study
KD Katariya, DV Reddy - Journal of Molecular Structure, 2022 - Elsevier
In search of novel biologically potent compounds, some new oxazolyl pyrimidines (7a-g)
have been prepared in the current investigation. All new compounds were characterized …
have been prepared in the current investigation. All new compounds were characterized …
An eco-friendly method for the synthesis of 1, 2, 4-triazole-Schiff base derivatives in aqueous medium and DFT calculations
A detailed optimization study was carried out for the synthesis of 1, 2, 4-triazole-Schiff base
derivatives. In previous studies, such reactions were performed either by conventional …
derivatives. In previous studies, such reactions were performed either by conventional …
[HTML][HTML] Addressing latent tuberculosis: New advances in mimicking the disease, discovering key targets, and designing hit compounds
A Campaniço, SG Harjivan, DF Warner… - International Journal of …, 2020 - mdpi.com
Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB)
remains a global public health concern arch. Our inability to eradicate this bacillus is …
remains a global public health concern arch. Our inability to eradicate this bacillus is …
Synthesis, biological evaluation, and molecular docking study of pyridine clubbed 1, 3, 4-oxadiazoles as potential antituberculars
ABSTRACT A series of pyridine clubbed 1, 3, 4-oxadiazole derivatives were efficiently
synthesized, characterized by standard spectral techniques and evaluated for their in vitro …
synthesized, characterized by standard spectral techniques and evaluated for their in vitro …