A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease

YP Singh, H Rai, G Singh, GK Singh, S Mishra… - European Journal of …, 2021 - Elsevier
Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …

[HTML][HTML] Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

J Feng, Y Zheng, M Guo, I Ares, M Martínez… - … Pharmaceutica Sinica B, 2023 - Elsevier
In recent years, growing awareness of the role of oxidative stress in brain health has
prompted antioxidants, especially dietary antioxidants, to receive growing attention as …

Application of quercetin in neurological disorders: From nutrition to nanomedicine

E Amanzadeh, A Esmaeili, S Rahgozar… - Reviews in the …, 2019 - degruyter.com
Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. The
antioxidant potential of quercetin has been studied from subcellular compartments, that is …

Physical activity vs. redox balance in the brain: brain health, aging and diseases

P Sutkowy, A Woźniak, C Mila-Kierzenkowska… - Antioxidants, 2021 - mdpi.com
It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …

Application of artificial intelligence in modeling of the doxorubicin release behavior of pH and temperature responsive poly (NIPAAm-co-AAc)-PEG IPN hydrogel

C Boztepe, A Künkül, M Yüceer - Journal of Drug Delivery Science and …, 2020 - Elsevier
Modeling of the drug release behavior of stimuli-responsive hydrogels is a domain of
steadily increasing academic and industrial importance. It is very difficult to accurately …

Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues

D Martins, E Gil-Martins, F Cagide, C da Fonseca… - Pharmaceuticals, 2023 - mdpi.com
Mescaline derivative (2C phenethylamines) drugs have been modified by the introduction of
a N-2-methoxybenzyl group to originate a new series of compounds with recognized and …

Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor

D Chavarria, S Benfeito, P Soares, C Lima… - European Journal of …, 2022 - Elsevier
Increased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely
linked to the neurodegeneration observed in Parkinson's Disease (PD). Caffeic acid (CA) …

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks

S Benfeito, C Fernandes, D Chavarria… - Journal of Medicinal …, 2023 - ACS Publications
Although the lipophilic triphenylphosphonium (TPP+) cation is widely used to target
antioxidants to mitochondria, TPP+-based derivatives have shown cytotoxicity in several …

[HTML][HTML] Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents

C Oliveira, D Bagetta, F Cagide, J Teixeira… - European journal of …, 2019 - Elsevier
The discovery of new chemical entities endowed with potent and selective
acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE) inhibitory activity is still a …

Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies

D Chavarria, C Fernandes, V Silva, C Silva… - European Journal of …, 2020 - Elsevier
Piperine has been associated with neuroprotective effects and monoamine oxidase (MAO)
inhibition, thus being an attractive scaffold to develop new antiparkinsonian agents …