Thiol-mediated uptake
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
Sulfur in dynamic covalent chemistry
AG Orrillo, RLE Furlan - Angewandte Chemie, 2022 - Wiley Online Library
Sulfur has been important in dynamic covalent chemistry (DCC) since the beginning of the
field. Mainly as part of disulfides and thioesters, dynamic sulfur‐based bonds (DSBs) have a …
field. Mainly as part of disulfides and thioesters, dynamic sulfur‐based bonds (DSBs) have a …
[HTML][HTML] Recent advances in developing small-molecule inhibitors against SARS-CoV-2
R Xiang, Z Yu, Y Wang, L Wang, S Huo, Y Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across
the entire world. Even though several COVID-19 vaccines are currently in distribution …
the entire world. Even though several COVID-19 vaccines are currently in distribution …
Oligonucleotide phosphorothioates enter cells by thiol‐mediated uptake
Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics where one phosphate
oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much …
oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
Approaches and materials for endocytosis-independent intracellular delivery of proteins
N Chen, Y He, M Zang, Y Zhang, H Lu, Q Zhao… - Biomaterials, 2022 - Elsevier
The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …
heart disease and neurodegenerative diseases, many important pharmacological targets …
Fluorogenic In Situ Thioacetalization: Expanding the Chemical Space of Fluorescent Probes, Including Unorthodox, Bifurcated, and Mechanosensitive Chalcogen …
Progress with fluorescent flippers, small-molecule probes to image membrane tension in
living systems, has been limited by the effort needed to synthesize the twisted push–pull …
living systems, has been limited by the effort needed to synthesize the twisted push–pull …
Selective, modular probes for thioredoxins enabled by rational tuning of a unique disulfide structure motif
Specialized cellular networks of oxidoreductases coordinate the dithiol/disulfide-exchange
reactions that control metabolism, protein regulation, and redox homeostasis. For probes to …
reactions that control metabolism, protein regulation, and redox homeostasis. For probes to …
Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue
R Martinent, S Tawffik, J López-Andarias… - Chemical …, 2021 - pubs.rsc.org
The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated
uptake is reported. This is important because most orthodox systems, including polycationic …
uptake is reported. This is important because most orthodox systems, including polycationic …
Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake
Integrins are cell surface proteins responsible for cell motility. Inspired by the rich disulfide
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …