In the past decades, adequate and well-planned management of chronic wounds has
reached an elevated importance to improve human's quality of life and extend life …

Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

Tissue engineering plays an important role in the production of skin equivalents for the
therapy of chronic and especially burn wounds. Actually, there exists no (cellularized) skin …

Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …

Background Commercially available tissue engineered skin remains elusive despite
extensive research because the multi-stratified anisotropic structure is difficult to replicate in …

Macroscale drug delivery (MDD) devices are engineered to exert spatiotemporal control
over the presentation of a wide range of bioactive agents, including small molecules …

Skin wounds are a major social and financial burden. However, current treatments are
suboptimal. The gradual comprehension of the finely orchestrated nature of intercellular …

There is enormous worldwide demand for therapies to promote the efficient resolution of
hard-to-heal wounds with minimal appearance of scarring. Recent in vitro studies with …

Scars are a consequence of cutaneous wound healing that can be both unsightly and
detrimental to the function of the tissue. Scar tissue is generated by excessive deposition of …

Wound healing is a highly evolved defense mechanism against infection and further injury. It
is a complex process involving multiple cell types and biological pathways. Mammalian …