Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

The rule of 5 (Ro5) is a set of in silico guidelines applied to drug discovery to prioritize
compounds with an increased likelihood of high oral absorption. It has been influential in …

Background We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a
platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for …

Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs,
including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an …

Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer …

Background The objective of this study was to develop and psychometrically evaluate a
general measure of patients' satisfaction with medication, the Treatment Satisfaction …

Background Intravenous bolus fluorouracil plus leucovorin is the standard adjuvant
treatment for colon cancer. The oral fluoropyrimidine capecitabine is an established …

Oral administration is an appealing route of delivering cancer treatments. However, the
gastrointestinal tract is characterized by specific and efficient physical, chemical, and …

Objective The emergence of various modes of administration for cancer treatment, including
oral administration, brings into focus the importance of patient preference for administration …

PURPOSE: To compare the response rate, efficacy parameters, and toxicity profile of oral
capecitabine with bolus intravenous (IV) fluorouracil plus leucovorin (5-FU/LV) as first-line …