[HTML][HTML] Signal transduction to the permeability transition pore
The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has
been thoroughly characterized functionally, yet remains an elusive molecular entity. The …
been thoroughly characterized functionally, yet remains an elusive molecular entity. The …
[HTML][HTML] Mechanisms of HTLV-1 persistence and transformation
M Boxus, L Willems - British journal of cancer, 2009 - nature.com
Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-
1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong …
1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong …
[HTML][HTML] mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells
M Silic-Benussi, E Sharova, F Ciccarese, I Cavallari… - Redox biology, 2022 - Elsevier
Abstract mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and is
associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously …
associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously …
Regulation of HTLV-1 transformation
KJ Ernzen, AR Panfil - Bioscience reports, 2022 - portlandpress.com
Human T-cell leukemia virus type 1 (HTLV-1) is the only identified oncogenic human
retrovirus. HTLV-1 infects approximately 5–10 million people worldwide and is the infectious …
retrovirus. HTLV-1 infects approximately 5–10 million people worldwide and is the infectious …
[HTML][HTML] Glucose metabolism and oxygen availability govern reactivation of the latent human retrovirus HTLV-1
A Kulkarni, M Mateus, CC Thinnes, JS McCullagh… - Cell chemical …, 2017 - cell.com
The human retrovirus HTLV-1 causes a hematological malignancy or neuroinflammatory
disease in∼ 10% of infected individuals. HTLV-1 primarily infects CD4+ T lymphocytes and …
disease in∼ 10% of infected individuals. HTLV-1 primarily infects CD4+ T lymphocytes and …
[HTML][HTML] HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
V Ciminale, F Rende, U Bertazzoni… - Frontiers in …, 2014 - frontiersin.org
HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and
expression pattern, but they differ substantially in their pathogenic properties. This review …
expression pattern, but they differ substantially in their pathogenic properties. This review …
Src kinases are important regulators of mitochondrial functions
E Hebert-Chatelain - The international journal of biochemistry & cell biology, 2013 - Elsevier
Mitochondria produce the most part of the energy used by the cells. This energetic
production occurs through the oxidative phosphorylation (OXPHOS) process. Mitochondrial …
production occurs through the oxidative phosphorylation (OXPHOS) process. Mitochondrial …
Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence
The 3'end of the human T-cell leukemia/lymphoma virus type-1 (HTLV-1) genome contains
four overlapping open reading frames (ORF) that encode regulatory proteins. Here, we …
four overlapping open reading frames (ORF) that encode regulatory proteins. Here, we …
[HTML][HTML] Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis
M Silic-Benussi, G Scattolin, I Cavallari… - Cell Death & …, 2018 - nature.com
Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are
currently incurable due to primary or secondary resistance to glucocorticoid-based …
currently incurable due to primary or secondary resistance to glucocorticoid-based …
Redox regulation of T-cell turnover by the p13 protein of human T-cell leukemia virus type 1: distinct effects in primary versus transformed cells
M Silic-Benussi, I Cavallari, N Vajente… - Blood, The Journal …, 2010 - ashpublications.org
The present study investigated the function of p13, a mitochondrial protein of human T-cell
leukemia virus type 1 (HTLV-1). Although necessary for viral propagation in vivo, the …
leukemia virus type 1 (HTLV-1). Although necessary for viral propagation in vivo, the …