Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of
function mutations in the genes encoding dystrophin, or the associated proteins, triggers …

We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember
families that share several features, including protein abundance, significant upregulation in …

Background Standard nonoperative therapy for acute muscle strains usually involves short-
term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear …

Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and
include keratin 7 (K7), K8, K18–K20, and K23. Genetically engineered mice that lack SEKs …

Cytolinkers are giant proteins that can stabilize cells by linking actin filaments, intermediate
filaments, and microtubules (MTs) to transmembrane complexes. Dystrophin is functionally …

Studies have reported that interactions between keratins (KRTs) and other proteins initiate
signaling cascades that regulate cell migration, invasion, and metastasis. In the current …

Desmin is a muscle-specific type III intermediate filament essential for proper muscular
structure and function. In human, mutations affecting desmin expression or promoting its …