Mammalian stress granules and P bodies at a glance
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …
based cellular compartments that assemble in response to stress. SGs and PBs form …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
P-bodies: composition, properties, and functions
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily
composed of translationally repressed mRNAs and proteins related to mRNA decay …
composed of translationally repressed mRNAs and proteins related to mRNA decay …
Stress granules and processing bodies in translational control
P Ivanov, N Kedersha… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …
Protein phase separation: a new phase in cell biology
Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …
organelles are separated by a membrane boundary from their surrounding milieu. There are …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules
RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein
aggregates or through phase separation into a liquid RNA/protein phase. Which model …
aggregates or through phase separation into a liquid RNA/protein phase. Which model …
The integral role of RNA in stress granule formation and function
D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …
(RNP) assemblies whose primary function is to promote cell survival by condensing …
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat
C Carrieri, L Cimatti, M Biagioli, A Beugnet, S Zucchelli… - Nature, 2012 - nature.com
Most of the mammalian genome is transcribed,,. This generates a vast repertoire of
transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) …
transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) …