Endothelial dysfunction is involved in the development of atherosclerosis, which precedes
asymptomatic structural vascular alterations as well as clinical manifestations of …

Endothelial dysfunction is now considered an important early event in the development of
atherosclerosis, which precedes gross morphological signs and clinical symptoms. The …

Advancing age is the major risk factor for the development of CVD (cardiovascular
diseases). This is attributable, in part, to the development of vascular endothelial …

Although episodic changes in shear stress have been proposed as the mechanism
responsible for the effects of exercise training on the vasculature, this hypothesis has not …

Prolonged sitting impairs endothelial function in the leg vasculature, and this impairment is
thought to be largely mediated by a sustained reduction in blood flow-induced shear stress …

We and others have recently reported that prolonged sitting impairs endothelial function in
the leg vasculature; however, the mechanism (s) remain unknown. Herein, we tested the …

Shear stress is an important stimulus to arterial adaptation in response to exercise and
training in humans. We recently observed significant reverse arterial flow and shear during …

We evaluated the effects of grape polyphenols in individuals classified with metabolic
syndrome (MetS). Men (n= 24) aged 30–70 y were randomly assigned to consume either a …

Lower limb exercise increases upper limb conduit artery blood flow and shear stress, and
leg exercise training can enhance upper limb vascular function. We therefore examined the …

Physical inactivity promotes the development of cardiovascular diseases. However, few data
exist examining the vascular consequences of short-term reductions in daily physical …