Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics

A Carnicer-Lombarte, ST Chen… - … in Bioengineering and …, 2021 - frontiersin.org
The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …

Toward higher-performance bionic limbs for wider clinical use

D Farina, I Vujaklija, R Brånemark, AMJ Bull… - Nature biomedical …, 2023 - nature.com
Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by
the user as belonging to their own body. Robotic limbs can convey information about the …

Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation

G Valle, N Katic Secerovic, D Eggemann… - Nature …, 2024 - nature.com
Artificial communication with the brain through peripheral nerve stimulation shows promising
results in individuals with sensorimotor deficits. However, these efforts lack an intuitive and …

Challenges and opportunities of implantable neural interfaces: From material, electrochemical and biological perspectives

Q Zeng, Z Huang - Advanced Functional Materials, 2023 - Wiley Online Library
The desirable implantable neural interfaces can accurately record bioelectrical signals from
neurons and regulate neural activities with high spatial/time resolution, facilitating the …

The Argo: a high channel count recording system for neural recording in vivo

K Sahasrabuddhe, AA Khan, AP Singh… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Decoding neural activity has been limited by the lack of tools available to record
from large numbers of neurons across multiple cortical regions simultaneously with high …

Neuromorphic hardware for somatosensory neuroprostheses

E Donati, G Valle - Nature Communications, 2024 - nature.com
In individuals with sensory-motor impairments, missing limb functions can be restored using
neuroprosthetic devices that directly interface with the nervous system. However, restoring …

Multifaceted understanding of human nerve implants to design optimized electrodes for bioelectronics

G Valle, G Aiello, F Ciotti, P Cvancara, T Martinovic… - Biomaterials, 2022 - Elsevier
Bioelectronic medicine is a promising venue for treatment of disabilities using implantable
neural interfaces. Peripheral neurostimulation of residual nerves recently enabled multiple …

Achieving long-term stability of thin-film electrodes for neurostimulation

P Oldroyd, GG Malliaras - Acta Biomaterialia, 2022 - Elsevier
Implantable electrodes that can reliably measure brain activity and deliver an electrical
stimulus to a target tissue are increasingly employed to treat various neurological diseases …

Direct laser writing of 3D electrodes on flexible substrates

MA Brown, KM Zappitelli, L Singh, RC Yuan… - Nature …, 2023 - nature.com
This report describes a 3D microelectrode array integrated on a thin-film flexible cable for
neural recording in small animals. The fabrication process combines traditional silicon thin …

Compliant peripheral nerve interfaces

V Paggi, O Akouissi, S Micera… - Journal of neural …, 2021 - iopscience.iop.org
Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which
are responsible for conducting sensory-motor information to and from the central nervous …