BACKGROUND The complexity of fertilization failure during assisted reproductive
technologies (ART) is often under-appreciated, as this failure can occur at any number of …

▪ Abstract Many eukaryotic proteins share a sequence designated as the zona pellucida (ZP)
domain. This structural element, present in extracellular proteins from a wide variety of …

Many secretory proteins and peptides are synthesized as inactive precursors that in addition
to signal peptide cleavage undergo post‐translational processing to become biologically …

Fertilization is the process by which haploid gametes, sperm and egg, unite to produce a
genetically distinct individual. Interest in this area has exploded in recent years. Here are …

All mammalian eggs are surrounded by a relatively thick extracellular coat, the zona
pellucida, that plays vital roles during oogenesis, fertilization, and preimplantation …

Purpose The oocyte-borne genetic causes leading to fertilization failure are largely
unknown. We aimed to identify novel human pathogenic variants (PV) and genes causing …

Zona pellucida (ZP) is a glycoproteinaceous translucent matrix that surrounds the
mammalian oocyte and plays a critical role in the accomplishment of fertilization. In humans …

All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …

The zona pellucida is an extracellular matrix consisting of three glycoproteins that surrounds
mammalian eggs and mediates fertilization. The primary structures of mouse ZP1, ZP2, and …

The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma
membrane of mammalian eggs. Its presence is essential for successful completion of …