Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Objective: In tumor patients, IL-6 appears to be one component of a consistent cancer-
associated cytokine network resulting in both a systemic immune stimulation and a …

Gastrointestinal cancer (GI) is a major health problem. Patients with gastric, pancreatic,
colorectal, bile duct and gall bladder cancer often have advanced disease at the time of …

Abstract Interleukin 6 (IL-6) was abundant in the tumor microenvironment and played
potential roles in tumor progression. In our study, the expression of IL-6 in tumor tissues from …

Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing
large number of macrophages. It has been suggested that these tumor‐associated …

The pleiotropic physiological functions of interleukin (IL-) 6 type cytokines range from
embryonic development and tissue homoeostasis to neuronal development and T cell …

Gastric cancer is one of leading causes of cancer‑related mortality worldwide and is a
notable disease due to its heterogeneity. Recently, numerous studies have investigated the …

When small proteins such as cytokines bind to their associated receptors on the plasma
membrane, they can activate multiple internal signaling cascades allowing information from …

The interleukin-6 (IL-6)/Janus kinase 2 (JAK2)/signal transducer and activator of
transcription 3 (STAT3) pathway mediates cell proliferation and migration. S-phase kinase …