When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …

Bernard–Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder
characterized by defects of the GPIb‐IX‐V complex, a platelet receptor for von Willebrand …

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis
(NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we …

Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets,
glycoprotein (GP) Ib–IX receptor complex has been long suggested to be a shear sensor …

Platelet-neutrophil interactions are important for innate immunity, but also contribute to the
pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that …

The process of hemostatic plug formation at sites of vascular injury crucially relies on the
large multimeric plasma glycoprotein von Willebrand factor (VWF) and its ability to recruit …

At the same time as biophysical and omics approaches are drilling deeper into the
molecular details of platelets and other blood cells, as well as their receptors and …

Abstract How glycoprotein (GP) Ib-IX complex on the platelet surface senses the blood flow
through its binding to the plasma protein von Willebrand factor (VWF) and transmits a signal …