Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

The seven-transmembrane G protein-coupled receptors activated by leukotrienes are
divided into two subclasses based on their ligand specificity for either leukotriene B4 or the …

The developing and mature central nervous system contains neural precursor cells
expressing the proteoglycan NG2. Some of these cells continuously differentiate to myelin …

Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …

The leukotrienes are important lipid mediators with immune modulatory and proinflammatory
properties. Classical bioactions of leukotrienes include chemotaxis, endothelial adherence …

The PC12 cell line is a classical neuronal cell model due to its ability to acquire the
sympathetic neurons features when deal with nerve growth factor (NGF). In the present …

Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in
asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader …

Arachidonic acid (all-cis-5, 8, 11, 14-eicosatetraenoic acid, AA) is an essential constituent of
cellular membranes, which is released by tightly regulated phospholipase cleavage …

Unveiling the mechanisms participating in the damage and repair of traumatic brain injury
(TBI) is fundamental to develop new therapies. The P2Y-like GPR17 receptor has recently …

Growing evidence suggests that alterations of the inflammatory/immune system contribute to
the pathogenesis of major depression and that inflammatory processes may influence the …