The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Research progress of natural small-molecule compounds related to tumor differentiation

X He, Y Liao, J Liu, S Sun - Molecules, 2022 - mdpi.com
Tumor differentiation is a therapeutic strategy aimed at reactivating the endogenous
differentiation program of cancer cells and inducing cancer cells to mature and differentiate …

The effects of dietary fermented soybean meal supplementation on the growth, antioxidation, immunity, and mTOR signaling pathway of juvenile coho salmon …

Q Zhang, Q Yang, M Guo, F Li, M Qin, Y Xie, J Xu, Y Liu… - Fishes, 2023 - mdpi.com
This experiment aims to investigate the effects of partial replacement of fish meal (FM) by
soybean meal (SBM) and/or fermented soybean meal (FSBM) on the growth, serum …

5-Demethylnobiletin inhibits cell proliferation, downregulates ID1 expression, modulates the NF-κB/TNF-α pathway and exerts antileukemic effects in AML Cells

PY Chen, CY Wang, EC Tsao, YT Chen, MJ Wu… - International journal of …, 2022 - mdpi.com
Acute myeloid leukemia (AML) is characterized by the dysregulation of hematopoietic cell
proliferation, resulting in the accumulation of immature myeloid cells in bone marrow. 5 …

Noncoding RNAs controlling oxidative stress in cancer

P Holvoet - Cancers, 2023 - mdpi.com
Simple Summary Mitochondria in cancer cells produce reactive oxygen species, inducing a
vicious cycle between oxidative stress, genomic instability, and cancer development …

8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment

PS Wu, CY Wang, HJ Hsu, JH Yen, MJ Wu - Biomolecules, 2023 - mdpi.com
Background: 8-hydroxydaidzein (8-OHD) is a compound derived from daidzein, known for its
anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia …

Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking

Y Chai, F Chen, Z Li, P Yang, Q Zhou, W Liu… - Clinical and Translational …, 2023 - Springer
Background Salidroside is a phenolic natural product, which is a kind of Rhodiola rosea. It
has been confirmed that it has inhibitory effects on chronic myeloid leukemia, but the specific …

Doxycycline Decreases Atherosclerotic Lesions in the Aorta of ApoE-⁄- and Ovariectomized Mice with Correlation to Reduced MMP-2 Activity

KE Rodrigues, A Azevedo, PR Gonçalves… - International Journal of …, 2022 - mdpi.com
Atherogenic events promote changes in vessel walls, with alteration of the redox state, and
increased activity of matrix metalloproteinases (MMPs). Thus, this study aims to evaluate …

The protective mechanism of Afuresertib against esophageal cancer

B Min, Y Wang, F Liang, CX Wang, F Wang… - Disease …, 2022 - Wiley Online Library
Esophageal cancer (EC) is a common malignant tumor of the digestive system. Exploring
the molecular biological mechanism of EC will help to clarify its carcinogenesis mechanism …

Phytochemical constituents and antileukemic effects of Juniperus oxycedrus extract

BT Turah, Dİ Acar, SK Gultehin, İG Albayrah… - Biotechnologia …, 2022 - search.proquest.com
Aim. Many genetic and environmental factors can be effective in the process of
cancerization. Preventing the progression of leukemia may be possible by controlling the …