The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …
neuronal dysfunctionality which results in disability and human life-threatening events. In …
Research progress of natural small-molecule compounds related to tumor differentiation
X He, Y Liao, J Liu, S Sun - Molecules, 2022 - mdpi.com
Tumor differentiation is a therapeutic strategy aimed at reactivating the endogenous
differentiation program of cancer cells and inducing cancer cells to mature and differentiate …
differentiation program of cancer cells and inducing cancer cells to mature and differentiate …
The effects of dietary fermented soybean meal supplementation on the growth, antioxidation, immunity, and mTOR signaling pathway of juvenile coho salmon …
Q Zhang, Q Yang, M Guo, F Li, M Qin, Y Xie, J Xu, Y Liu… - Fishes, 2023 - mdpi.com
This experiment aims to investigate the effects of partial replacement of fish meal (FM) by
soybean meal (SBM) and/or fermented soybean meal (FSBM) on the growth, serum …
soybean meal (SBM) and/or fermented soybean meal (FSBM) on the growth, serum …
5-Demethylnobiletin inhibits cell proliferation, downregulates ID1 expression, modulates the NF-κB/TNF-α pathway and exerts antileukemic effects in AML Cells
Acute myeloid leukemia (AML) is characterized by the dysregulation of hematopoietic cell
proliferation, resulting in the accumulation of immature myeloid cells in bone marrow. 5 …
proliferation, resulting in the accumulation of immature myeloid cells in bone marrow. 5 …
Noncoding RNAs controlling oxidative stress in cancer
P Holvoet - Cancers, 2023 - mdpi.com
Simple Summary Mitochondria in cancer cells produce reactive oxygen species, inducing a
vicious cycle between oxidative stress, genomic instability, and cancer development …
vicious cycle between oxidative stress, genomic instability, and cancer development …
8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment
Background: 8-hydroxydaidzein (8-OHD) is a compound derived from daidzein, known for its
anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia …
anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia …
Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking
Y Chai, F Chen, Z Li, P Yang, Q Zhou, W Liu… - Clinical and Translational …, 2023 - Springer
Background Salidroside is a phenolic natural product, which is a kind of Rhodiola rosea. It
has been confirmed that it has inhibitory effects on chronic myeloid leukemia, but the specific …
has been confirmed that it has inhibitory effects on chronic myeloid leukemia, but the specific …
Doxycycline Decreases Atherosclerotic Lesions in the Aorta of ApoE-⁄- and Ovariectomized Mice with Correlation to Reduced MMP-2 Activity
KE Rodrigues, A Azevedo, PR Gonçalves… - International Journal of …, 2022 - mdpi.com
Atherogenic events promote changes in vessel walls, with alteration of the redox state, and
increased activity of matrix metalloproteinases (MMPs). Thus, this study aims to evaluate …
increased activity of matrix metalloproteinases (MMPs). Thus, this study aims to evaluate …
The protective mechanism of Afuresertib against esophageal cancer
B Min, Y Wang, F Liang, CX Wang, F Wang… - Disease …, 2022 - Wiley Online Library
Esophageal cancer (EC) is a common malignant tumor of the digestive system. Exploring
the molecular biological mechanism of EC will help to clarify its carcinogenesis mechanism …
the molecular biological mechanism of EC will help to clarify its carcinogenesis mechanism …
Phytochemical constituents and antileukemic effects of Juniperus oxycedrus extract
BT Turah, Dİ Acar, SK Gultehin, İG Albayrah… - Biotechnologia …, 2022 - search.proquest.com
Aim. Many genetic and environmental factors can be effective in the process of
cancerization. Preventing the progression of leukemia may be possible by controlling the …
cancerization. Preventing the progression of leukemia may be possible by controlling the …