Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …

Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …

Medicinal plants have been the basis for discovery of various important marketed drugs.
Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline …

There are four subtypes of adenosine receptors (ARs), named A1, A2A, A2B and A3, all of
which are G protein-coupled receptors (GPCRs). Locally produced adenosine is a …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR)
antagonists described in the literature. They exhibit micromolar affinities and are non …