Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Development of obesity is primarily the result of imbalance between energy intake and
energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

Obesity results when energy intake exceeds energy expenditure. Naturally occurring genetic
mutations, as well as ablative lesions, have shown that the brain regulates both aspects of …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

The metabolic effects of obesity have made this highly prevalent disease one of the most
common risk factors for diabetes, hypertension, and atherosclerosis, the leading causes of …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH