Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial
growth factor domain-containing protein] family consists of three proteins in vertebrates …

Hedgehog, a developmental morphogen, and its downstream signalling have recently been
associated with metabolic control. Sonic hedgehog signalling (Shh) is a significant pathway …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in
embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic …

The vascular endothelium plays a vital role in regulating normal vascular function.
Endothelial lining maintains the balance of thrombolytic and fibrinolytic microenvironment in …

Background: Dipper and non-dipper hypertension are different clinical forms of essential
hypertension. In this study, the effect of circadian blood pressure changes on serum SCUBE …

Tongue squamous cell carcinoma (TSCC) is the main pathologic subtype of oral cancer, and
the current therapeutic effect is far from satisfactory. The signal peptide-CUB-EGF domain …

Aims The therapeutic potential of Hedgehog (Hh) signalling agonists for vascular diseases
is of growing interest. However, molecular and cellular mechanisms underlying the role of …

Background: This study aims to identify circulating biomarkers by using proteomic analysis
associated with sac shrinkage or expansion in patients undergoing endovascular aneurysm …

OBJECTIVE: The aim of the study was to evaluate the protective effects of alpha-lipoic acid
(ALA) on the liver, oxidative parameters, and signal peptide-CUB-epidermal growth factor …