Inflammation is among the core causatives of male infertility. Despite male infertility being a
serious global issue,“bits and pieces” of its complex etiopathology still remain missing …

Oxidative stress is an important factor for development of male infertility because of very high
rate of cell division and mitochondrial oxygen consumption in testicular tissue as well as …

Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in
Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are …

Reactive oxygen species (ROS) are an integral component of sperm developmental
physiology, capacitation, and function. Elevated ROS levels, from processes such as …

Spermatogenesis is an extremely active replicative process capable of generating approxi
mately 1,000 sperm a second. The high rates of cell division inherent in this process imply …

Oxidative stress results from the production of oxygen radicals in excess of the antioxidant
capacity of the stressed tissue. Many conditions or events associated with male infertility are …

The role of free radicals in normal cellular functions and different pathological conditions has
been a focus of pharmacological studies in the recent past. Reactive oxygen species (ROS) …

Urosepsis is defined as sepsis caused by a urogenital tract infection. Urosepsis in adults
comprises approximately 25% of all sepsis cases, and is in most cases due to complicated …

Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell
population ultimately develops from undifferentiated mesenchymal-like stem cells present in …

Cholesterol is a vital component of cellular membranes, and is the substrate for biosynthesis
of steroids, oxysterols and bile acids. The mechanisms directing the intracellular trafficking of …