Quaternary ammonium salts: insights into synthesis and new directions in antibacterial applications

Z Zhou, S Zhou, X Zhang, S Zeng, Y Xu… - Bioconjugate …, 2023 - ACS Publications
The overuse of antibiotics has led to the emergence of a large number of antibiotic-resistant
genes in bacteria, and increasing evidence indicates that a fungicide with an antibacterial …

Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus

H Liu, T Xu, Z Xue, M Huang, T Wang… - ACS Infectious …, 2024 - ACS Publications
The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

A new discovery of unique 13-(benzimidazolylmethyl) berberines as promising broad-spectrum antibacterial agents

H Sun, ZZ Li, P Jeyakkumar, ZL Zang… - Journal of Agricultural …, 2022 - ACS Publications
A new hybridization of berberine and benzimidazoles was performed to produce 13-
(benzimidazolylmethyl) berberines (BMB) as potentially broad-spectrum antibacterial agents …

SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria

EME Dokla, NS Abutaleb, SN Milik, EAEA Kandil… - European Journal of …, 2023 - Elsevier
Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life.
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …

Unique azolyl acylhydrazonyl hybridization of aloe emodins to access potential antibacterial agents

YX Wang, Z Deng, A Bibi, B Fang… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary A type of unique azole‐hybridized acylhydrazonyl aloe emodins
(AAEs) were developed as new antibacterial agents for combating bacterial infections …

Exploring the dual effect of novel 1, 4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory …

AM Malebari, HEA Ahmed, SK Ihmaid, AM Omar… - Bioorganic …, 2023 - Elsevier
COVID-19 and associated substantial inflammations continue to threaten humankind
triggering death worldwide. So, the development of new effective antiviral and anti …

Lipophilic Ga complex with broad-spectrum antimicrobial activity and the ability to overcome gallium resistance in both Pseudomonas aeruginosa and Staphylococcus …

Z Wang, J Li, BM Benin, B Yu, SD Bunge… - Journal of Medicinal …, 2021 - ACS Publications
Antibiotic resistance (AR) necessitates the discovery of new antimicrobials with alternative
mechanisms of action to those employed by conventional antibiotics. One such strategy …

Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly …

ZL Zang, YX Wang, N Battini, WW Gao… - European Journal of …, 2024 - Elsevier
The global microbial resistance is a serious threat to human health, and multitargeting
compounds are considered to be promising to combat microbial resistance. In this work, a …

Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin-and vancomycin-resistant Staphylococcus aureus

MM Elsebaie, HTN El-Din, NS Abutaleb… - European Journal of …, 2022 - Elsevier
A set of structurally related diphenylurea derivatives bearing aminoguanidine moiety were
synthesized, and their antibacterial activity was assessed against a panel of multi-drug …

Antibacterial and anti-quorum sensing activities of a substituted thiazole derivative against methicillin-resistant Staphylococcus aureus and other multidrug-resistant …

YM Ibrahim, AM Abouwarda, T Nasr, FA Omar… - Microbial …, 2020 - Elsevier
Management of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) is
still challenging. We herein report the antibacterial and anti-quorum sensing (anti-QS) …