RNA binding proteins (RBPs) regulate all aspects in the life cycle of RNA molecules. To
elucidate the elements that guide RNA specificity, regulatory mechanisms, and functions of …

At each active protein-encoding gene, nascent RNA is tethered to the DNA axis by
elongating RNA polymerase II (Pol II) and is continuously altered by splicing and other …

Summary N 6-methyladenosine (m 6 A) modification occurs co-transcriptionally and impacts
pre-mRNA processing; however, the mechanism of co-transcriptional m 6 A-dependent …

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with
physiological decline and stem cell exhaustion. However, whether the circadian machinery …

Cells must coordinate the activation of thousands of replication origins dispersed throughout
their genome. Active transcription is known to favor the formation of mammalian origins …

Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

Highlights•Intron retention is a widespread feature of mammalian gene expression
programs.•Retained introns are associated with post-transcriptional alternative …

Intron retention is a type of alternative splicing where one or more introns remain unspliced
in a polyadenylated transcript. Although many viral systems are known to translate proteins …

MYC is dysregulated in> 50% of cancers, but direct targeting of MYC has been clinically
unsuccessful. Targeting downstream MYC effector pathways represents an attractive …

Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …