Peptidylglycine α-amidating enzyme (α-AE) can be used in an in vitro reaction to convert C-
terminal glycine-extended peptides to peptide hormones with a C-terminal amino acid …

Melanocortin peptides, the collective term for α‐, β‐, and γ‐melanocyte‐stimulating hormone
(α‐, β‐, γ‐MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient …

This volume covers all aspects of melanin pigmentation, providing a concise,
comprehensive picture of new knowledge gained at the frontiers of research. It draws …

Peptide and protein biological activities depend on their three dimensionals structures in the
free state and when interacting with their receptors/acceptors. The backbone conformations …

[Nle4, Xxx5, D-Phe7, Yyy10, Glyn]-a-MSH4_13-NH2 and Ac-[Nle4, Xxx6 7891011, D-Phe7,
Yyy10]-a-MSH4. 10-NH2, where Xxx= Glu or Asp and Yyy= Lys, Orn, Dab, or Dpr. Formation …

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating
hormone-(4-10)-NH2 Page 1 3454 J. Med. Chem. 1995, 38, 3454-3461 Expedited Articles …

MSH4_12-NH2 (), Ac-[Nle4]-a-MSH4_n-NH2 (), Ac-[Nle4]-a-MSH4_10-NH2 (a), and Ac-a-
MSH4_10-NH2 (O) as determined on the frog (R. pipiens) skin assay. was reported to be a …

Objective.—To determine the efficacy of short-term administration of a synthetic analogue of
α-melanotropin,[Nle 4 D-Phe 7](NDP)—α-melanocyte-stimulating hormone (MSH), in …

Purpose: We evaluated the erectogenic properties of a new cyclic alpha-melanocyte-
stimulating hormone analogue, Melanotan-II, to treat men with psychogenic erectile …

The melanocortin-1 receptor (MC1R) is a seven-transmembrane (TM) G-protein-coupled
receptor whose natural ligands are the melanocortin peptides, adrenocorticotropic hormone …